Quantifying Insulin Sensitivity and Entero-Insular Responsiveness to Hyper- and Hypoglycemia in Ferrets
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منابع مشابه
Quantifying Insulin Sensitivity and Entero-Insular Responsiveness to Hyper- and Hypoglycemia in Ferrets
Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques to quantify aspects of diabetes pathophysiology in the ferret. Glycemic clamps are the gold standard technique to assess both insulin sensitivity and insulin secretion in humans and animal models of diabetes. We therefore sought to develop...
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The concept of an entero-insular axis has its origins in the 19th Century, after the observation that greater amounts of glucose could be given orally rather than intravenously without producing glycosuria. However, convincing evidence that the gut is able to modify the insulin response to an oral glucose load was produced by two groups of investigators in the 1960s, who showed that oral glucos...
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SHIBATA, O. Adrenal Cortical and Medullary Responsiveness to Insulin-induced Hypoglycemia. Tohoku J. exp. Med., 1971, 105 (1), 27-33 Experiments were done in dogs anesthetized with sodium pentobarbital. Adrenal venous blood was collected and analyzed for 17-hydroxycorticosteroids (17-OHCS), adrenaline and noradrenaline. The animals were injected intravenously with 1.0, 0.5, 0.1 and 0.05 U/kg of...
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Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated. For this purpose, livers were perfused with a saturating concentration of 2 mM glycerol, 5 mM L-alanine or 5 mM L-glutamine as gluconeogenic substrates. All experiments were performed 1 h after an ip injection of saline (CN group) or 1 IU/kg of insulin (IN group). The IN group showed higher ...
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In individuals with type 1 diabetes, hypoglycemia is a common consequence of overinsulinization. Under conditions of insulin-induced hypoglycemia, glucagon is the most important stimulus for hepatic glucose production. In contrast, during euglycemia, insulin potently inhibits glucagon's effect on the liver. The first aim of the present study was to determine whether low blood sugar augments glu...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0090519